Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans

نویسندگان

  • He‐Ping Chen
  • Zhen‐Zhu Zhao
  • Zheng‐Hui Li
  • Ze‐Jun Dong
  • Kun Wei
  • Xue Bai
  • Ling Zhang
  • Chun‐Nan Wen
  • Tao Feng
  • Ji‐Kai Liu
چکیده

A variety of novel natural products with significant bioactivities are produced by the basidiomycete Boreostereum vibrans. In the present study, we describe 16 novel natural oximes and oxime esters with a vibralactone backbone, vibralactoximes, which were isolated from the scale-up fermentation broth of B. vibrans. Their structures were determined through extensive spectroscopic analyses. These compounds represent the first oxime esters from nature. The hypothetical biosynthetic pathway of these compounds was also proposed. Seven compounds exhibited significant pancreatic lipase inhibitory activity, while ten compounds exhibited cytotoxicities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), with IC50 values comparable with those of cisplatin.

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Derivatives of vibralactone from cultures of the basidiomycete Boreostereum vibrans.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2016